When Queen Isabel died in 1504, her will stated that her daughter Juana should succeed her on the throne. Unfortunately, Juana suffered from schizophrenia and this wasn’t helped by her husband Felipe’s frequent affairs. Following his death after short illness (though some believed that he had been poisoned by Juana’s father, Fernando), Juana went mad and her father Fernando acted as regent until his death in 1516.
After Fernando’s death, Carlos became King and he was to become one of the most powerful rulers in the world. In 1520, he was crowned Carlos V, Emperor of the Holy Roman Empire, an empire on which “the sun never set”. When his father Felipe died in 1506 he became Duke of Burgundy and ruler of the Netherlands, and on the death of his grandfather Fernando, he became King of the Two Sicilies and of Spain. His plan was to establish his court and residence in Granada to commemorate the Catholic Monarchs conquest of the Moor’s last stronghold and with this aim, he commissioned the Carlos V Palace.
Having become a European leader after a power struggle with France, he decided to retire and split his empire between his brother Fernando and his son Felipe. In 1556, his son became King of Spain and Carlos retired to a Spanish monastery in Yuste where he died in 1558.